Plasminogen supplementation improves lysis of inflammatory retained traumatic hemothorax
Retained hemothorax is a highly inflammatory environment with secondary plasminogen depletion that reduces fibrinolytic capacity. Plasminogen activator inhibitor 1 inhibition of tPA appears to be an unlikely mechanism of clinical IPFT failure. These findings challenge the role of IPFT for rHTX and support upfront surgical intervention. Future studies exploring plasminogen supplementation in IPFT as a therapeutic strategy for poor surgical candidates is warranted.
Authors
- Angela Sauaia (ORCID: https://orcid.org/0000-0002-8493-389X)
- Christopher D. Barrett (ORCID: https://orcid.org/0000-0001-9720-8155)
- Jessica Veatch (ORCID: https://orcid.org/0000-0001-9195-0308)
- Collin M White
- Peter K. Moore (ORCID: https://orcid.org/0000-0001-6446-067X)
- Hunter B. Moore (ORCID: https://orcid.org/0000-0002-5939-3828)
- Reynold Henry (ORCID: https://orcid.org/0000-0002-2662-5485)
- Ernest Eugene Moore (ORCID: https://orcid.org/0000-0002-0419-4848)
- Andrew Kamien
- Miguel Matos (ORCID: https://orcid.org/0000-0003-3040-4965)
- Olabisi Sheppard
- Flobater I. Gawargi (ORCID: https://orcid.org/0000-0003-0877-4521)
- John F. Tierney (ORCID: https://orcid.org/0000-0003-0993-5534)
- Charity H. Evans
- Michael B. Yaffe (ORCID: https://orcid.org/0000-0002-9547-3251)
- Grace E. Volk (ORCID: https://orcid.org/0009-0003-9982-2409)
- Emily Cantrell
- Zachary M. Bauman (ORCID: https://orcid.org/0000-0001-9409-2193)
- Elizabeth R Maginot
- James G. Chandler
- Gina Lamb
- Trace B Moody
- Isabella M Bernhardt
- Maddie R. Cloonan
- Dylan C. Hiser
- Kyle S. Sextro
Institutions
- University of Nebraska–Lincoln (US)
- Health First (US)
- Denver School of Nursing (US)
Publication Details
- Journal
- The Journal of Trauma: Injury, Infection, and Critical Care
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1097/ta.0000000000004687
- Primary Topic
- Pleural and Pulmonary Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00