PTGDS deficiency as a driver of M2 macrophage polarization and immunosuppressive microenvironment in esophageal squamous cell carcinoma: an experimental study
PTGDS deficiency promotes immunosuppressive TME remodeling and predicts unfavorable clinical outcomes in ESCC, which might be a potential prognostic biomarker in ESCC.
Authors
- Xianwen Chen (ORCID: https://orcid.org/0000-0001-9262-2568)
- Wanli Lin (ORCID: https://orcid.org/0000-0002-2820-8765)
- Zhengang Zhao
- Jianhua Fu (ORCID: https://orcid.org/0000-0002-8451-3705)
- Yujie Xie (ORCID: https://orcid.org/0000-0002-2260-9242)
- Jian Zhong (ORCID: https://orcid.org/0000-0002-5851-0041)
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- Sichuan University (CN)
- Shaanxi Research Association for Women and Family (CN)
- Sun Yat-sen University Cancer Center (CN)
- Gaozhou People's Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1097/js9.0000000000002589
- Citations
- 1
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01