Tumor cell spheroid-induced suppression of primary human cytotoxic T cells as a scalable <i>in vitro</i> model of exhaustion
This comprehensive characterization of the phenotype of in vitro primary human CTL, including a suppressed state, should facilitate their use in basic research, the development of CTL-targeting therapeutics and the determination of their mechanism of action.
Authors
- Abdullah S. M. Aljohani (ORCID: https://orcid.org/0000-0003-4017-7698)
- Yi-Wei Shi (ORCID: https://orcid.org/0000-0003-2169-8789)
- Po‐Han Chou (ORCID: https://orcid.org/0000-0002-4148-457X)
- Lawrence E. Mason
- L. Huynh
- Christoph Wülfing
- Tressan Grant (ORCID: https://orcid.org/0009-0000-1177-9388)
- John S. Bridgeman (ORCID: https://orcid.org/0000-0002-2857-6031)
- Andrew Herman
- Hanin Alamir (ORCID: https://orcid.org/0000-0003-3688-8454)
- Amal Alsubaiti
- Christopher J. Holland
- Maryam Alismail
Institutions
- University of Bristol (GB)
- Immunocore (United Kingdom) (GB)
- Research Institute of Dallas (US)
- University of Bath (GB)
Publication Details
- Journal
- Immunotherapy Advances
- Published
- 2024-12-30
- DOI
- https://doi.org/10.1093/immadv/ltaf023
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Bristol
- Medical Research Council