Implementation of an Online Drug–Drug Interaction Screener for the STRIVE Ensitrelvir Trial for COVID-19
DDI resources for investigational medications like ensitrelvir, with high DDI potential, are crucial for safe conduct of clinical trials. Effective implementation requires a multidisciplinary, iterative approach that incorporates real-time feedback from trial sites.
Authors
- Nayon Kang
- Joshua P Havens (ORCID: https://orcid.org/0000-0001-9894-615X)
- Courtney Vail Fletcher (ORCID: https://orcid.org/0000-0002-3703-7849)
- Phiona Kaweesi Nabaggala
- Page Crew (ORCID: https://orcid.org/0000-0003-2803-4264)
- Adit A. Ginde (ORCID: https://orcid.org/0000-0003-2325-206X)
- Lianne Siegel (ORCID: https://orcid.org/0000-0001-9440-9146)
- Jason V. Baker (ORCID: https://orcid.org/0000-0002-5542-1545)
- Shikha Vasudeva
- Anne Davis‐Karim (ORCID: https://orcid.org/0000-0002-2801-3909)
- Birgit Grund (ORCID: https://orcid.org/0000-0003-4275-7880)
- Sho Saito
- Derek W. Russell (ORCID: https://orcid.org/0000-0002-2716-1344)
- Alfredo J Mena Lora (ORCID: https://orcid.org/0000-0002-8337-757X)
- Ryosuke Shimizu (ORCID: https://orcid.org/0000-0001-9666-8678)
- Alpha Diallo (ORCID: https://orcid.org/0000-0001-9642-0584)
- Katrina Harper
- Ahmad Mourad (ORCID: https://orcid.org/0000-0002-3149-597X)
- Marcelo Losso (ORCID: https://orcid.org/0000-0002-4273-4833)
- Kyle C. Molina (ORCID: https://orcid.org/0000-0002-6764-5984)
- Mina Pak
- Jacqueline Nordwall
- Lucy Chung
Institutions
- University of Minnesota (US)
- Nebraska Medical Center (US)
- Duke University (US)
- University of Minnesota System (US)
- University of Alabama at Birmingham (US)
- University of Illinois Chicago (US)
- Clinical Research Institute (US)
- The Coordinating Center (US)
- National Center for Global Health and Medicine (JP)
- Hospital Ramos Mejía (AR)
- Agence Nationale de Recherches sur le Sida et les Hépatites Virales (FR)
- Shionogi (Japan) (JP)
- Shionogi (United States) (US)
- National Institute of Allergy and Infectious Diseases (US)
- Minnesota Department of Health (US)
- Hennepin Healthcare Research Institute (US)
- University of Nebraska Medical Center (US)
- The University of Texas Southwestern Medical Center (US)
- Uganda Virus Research Institute (UG)
- University of Colorado Denver (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1093/ofid/ofaf327
- Primary Topic
- COVID-19 Clinical Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Norges Idrettshøgskole
- National Institutes of Health
- Instituto Nacional do Câncer, Ministério da Saúde
- National Institute of Allergy and Infectious Diseases