Characterization of Bruch's Membrane Formation in Human Fetal Retina and De Novo Membrane Synthesis by hPSC-Derived Retinal Pigment Epithelium
BrM-like membrane synthesis in hPSC-derived RPE largely recapitulates the temporal sequence seen in human development, excluding elastin. These support the utility of hPSC-derived RPE in in vitro systems to model RPE/retina interactions in health and disease, and inform cell therapy approaches, as de novo BrM-like membrane has the potential to support transplanted donor RPE.
Authors
- R. A. Pearson (ORCID: https://orcid.org/0000-0002-1107-1969)
- Matthew J. Branch (ORCID: https://orcid.org/0000-0002-8734-0037)
- Philippa Harding (ORCID: https://orcid.org/0000-0003-0763-3516)
- Emily P. Lanning (ORCID: https://orcid.org/0000-0001-9682-1732)
- Robin R. Ali (ORCID: https://orcid.org/0000-0003-3126-6517)
- Alexander J. Smith (ORCID: https://orcid.org/0000-0002-3034-9137)
- Miriam Margari
Institutions
- Guy's Hospital (GB)
- King's College London (GB)
- Cell and Gene Therapy Catapult (GB)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1167/iovs.66.6.40
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00