Trends and hotspots in targeted therapy resistance research for renal cell carcinoma: a bibliometric and visualization analysis
Bibliometric analysis of research on molecular targeted therapy resistance in renal cell carcinoma revealed a clear trajectory and rapidly increasing trend in this field. The impact of the tumor microenvironment, particularly the roles of renal cancer stem cells and epithelial-mesenchymal transition, has garnered significant attention. Additionally, the combination of anti-PD-L1/PD-1 and targeted drugs, as well as the involvement of miRNA, have emerged as key areas of focus. As understanding of this field deepens, future research is expected to uncover novel therapeutic targets and more effectively overcome the challenges of targeted therapy resistance in renal cell carcinoma, ultimately improving patient outcomes.
Authors
- Ze Wang (ORCID: https://orcid.org/0000-0002-5398-6008)
- Chao‐Hui Zheng (ORCID: https://orcid.org/0000-0003-0157-5167)
- Jun Jiang (ORCID: https://orcid.org/0000-0001-9408-2972)
- Xiaodu Xie (ORCID: https://orcid.org/0000-0003-1889-5570)
- Weihua Lan (ORCID: https://orcid.org/0000-0003-1186-195X)
- Peng Tang (ORCID: https://orcid.org/0000-0003-1658-6774)
- Jian Chen (ORCID: https://orcid.org/0000-0001-8010-2549)
- Zi-Qian Wang (ORCID: https://orcid.org/0000-0003-3715-1593)
- Junying Zhang (ORCID: https://orcid.org/0000-0002-4860-8774)
- Jing Xu (ORCID: https://orcid.org/0000-0001-8542-2445)
- Qiuli Liu (ORCID: https://orcid.org/0000-0002-9532-5654)
- Haiyang Xiao
Institutions
- Army Medical University (CN)
- Zhengzhou University (CN)
- Daping Hospital (CN)
- Chongqing Medical and Pharmaceutical College (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1007/s12672-025-02772-0
- Citations
- 1
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- Army Medical University