Nonlesional Skin and Blood Interferon Scores Among Patients With a History of Cutaneous Lupus
This cross-sectional study found that ISGs, as represented by IFN scores, in nonlesional skin and PBMCs were elevated in patients with lupus with a history of CLE compared with patients without CLE, suggesting that patients with lupus with and without CLE comprise 2 endotypes, with stronger IFN dysregulation occurring in patients with CLE.
Authors
- Céline C. Berthier (ORCID: https://orcid.org/0000-0003-3539-1075)
- Mitra Padideh Maz (ORCID: https://orcid.org/0000-0002-2359-0862)
- Craig J. Dobry (ORCID: https://orcid.org/0000-0002-1468-1156)
- Benjamin Klein (ORCID: https://orcid.org/0000-0002-3412-5536)
- Svenja Henning (ORCID: https://orcid.org/0000-0002-7895-6729)
- Lam C. Tsoi (ORCID: https://orcid.org/0000-0003-1627-5722)
- Johann Eli Gudjonsson (ORCID: https://orcid.org/0000-0002-0080-0812)
- Joanne Michelle Kahlenberg (ORCID: https://orcid.org/0000-0002-4006-8945)
- Amy Hurst
- Rachael Bogle (ORCID: https://orcid.org/0000-0003-3544-3023)
- Amber Young
Institutions
- University of Groningen (NL)
- University of Michigan (US)
Publication Details
- Journal
- JAMA Dermatology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1001/jamadermatol.2025.1697
- Citations
- 3
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 5.00