Differential Associations of Dopamine and Serotonin With Reward and Punishment Processes in Humans
In this study, pharmacological manipulations of both dopamine and serotonin had measurable associations with reinforcement learning in humans. The selective associations with different components suggest that reinforcement learning tasks could form the basis of selective, mechanistically interpretable biomarkers to support treatment assignment.
Authors
- Yaniv Abir (ORCID: https://orcid.org/0000-0002-3725-9011)
- Harry Costello (ORCID: https://orcid.org/0000-0003-4490-9219)
- Quentin Dercon (ORCID: https://orcid.org/0000-0001-8264-347X)
- Terezie Sedlinská (ORCID: https://orcid.org/0000-0002-4768-7773)
- Anahit Mkrtchian (ORCID: https://orcid.org/0000-0001-9876-2852)
- Quentin J. M. Huys (ORCID: https://orcid.org/0000-0002-8999-574X)
- Zeguo Qiu (ORCID: https://orcid.org/0000-0003-3844-2683)
- Tore Erdmann (ORCID: https://orcid.org/0000-0002-3042-9882)
- Michael Browning (ORCID: https://orcid.org/0000-0001-9108-3144)
Institutions
- Okinawa Institute of Science and Technology Graduate University (JP)
- Oxford Health NHS Foundation Trust (GB)
- University of Oxford (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- JAMA Psychiatry
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1001/jamapsychiatry.2025.0839
- Citations
- 7
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 9.76