Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning
The study underscores the importance of the tumor microenvironment in influencing breast cancer metastasis to distant organs. We also established a comprehensive framework for understanding the mechanisms driving organotropism metastasis in breast cancer. Additionally, we identified key genes and signaling pathways associated with organ-specific metastasis, providing insights that may inform future studies on risk assessment and potential therapeutic targets for metastatic breast cancer.
Authors
- Hongbo Xie (ORCID: https://orcid.org/0000-0001-7916-7038)
- Xiujie Chen (ORCID: https://orcid.org/0000-0003-2423-8569)
- Denan Zhang (ORCID: https://orcid.org/0000-0002-5849-1477)
- Qing Jin (ORCID: https://orcid.org/0000-0001-9342-2963)
- Meizhu Xiao
- Lei Liu (ORCID: https://orcid.org/0000-0002-9995-9080)
- Min Zhang (ORCID: https://orcid.org/0009-0002-9012-9547)
- Zhijin Fu
- Yanjiao Li (ORCID: https://orcid.org/0000-0002-5359-3212)
Institutions
- Harbin Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1007/s12672-025-02905-5
- Citations
- 2
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Postdoctoral Scientific Research Development Fund of Heilongjiang Province
- National Natural Science Foundation of China
- Heilongjiang Provincial Postdoctoral Science Foundation