Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model
The antidepressant effects correlated with restored MBP, CNP, and IL-1β expression levels, suggesting that MBP/CNP deficiencies in depression may involve IL-1β elevation. In particular, combined enriched environment and fluoxetine accelerated behavioral recovery.
Authors
- Mengjun Geng
- Jinhong Han
- Yan Li (ORCID: https://orcid.org/0000-0002-7465-7705)
- Jingyang Gu (ORCID: https://orcid.org/0009-0000-0073-7457)
- Laipeng Feng
- Cong Liu (ORCID: https://orcid.org/0000-0002-9796-1371)
- Changhong Wang (ORCID: https://orcid.org/0000-0001-7578-4856)
- Jiao Dong
- Liqin Zhao (ORCID: https://orcid.org/0000-0003-4901-7471)
- Huiying Wang (ORCID: https://orcid.org/0000-0002-8811-1455)
- Qiujing Shao
Institutions
- Zhengzhou University (CN)
- Henan Psychiatric Hospital (CN)
- Henan Medical University (CN)
Publication Details
- Journal
- Behavioral and Brain Functions
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s12993-025-00282-1
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- National Natural Science Foundation of China