Targeting of acute myeloid leukemia by five-gene engineered T cells expressing transgenic T-cell receptor specific to WT1, chimeric antigenic receptor specific to GM-CSF receptor, bispecific T-cell engager specific to CD33, and tEGFR suicide gene sys

The presented strategy, utilizing a single piggyBac transposon vector, enables the complex redirection of T-cell specificity against acute myeloid leukemia by inserting TCR, CAR, BiTE constructs, along with a tEGFR gene suicide system.

Authors

Jana Rychlá
Martin Mucha (ORCID: https://orcid.org/0000-0002-1735-8055)
Martin Štach (ORCID: https://orcid.org/0000-0003-0655-2706)
Pavel Otáhal (ORCID: https://orcid.org/0000-0002-5513-4159)
Šárka Vaníková (ORCID: https://orcid.org/0000-0003-4011-5294)
Kristýna Šmilauerová (ORCID: https://orcid.org/0000-0002-4855-4550)

Institutions

Charles University (CZ)
Institute of Haematology and Blood Transfusion (CZ)

Publication Details

Journal: Immunotherapy Advances
Published: 2024-12-30
DOI: https://doi.org/10.1093/immadv/ltaf022
Citations: 1
Primary Topic: CAR-T cell therapy research
Type: article
Field-Weighted Citation Impact: 0.28

Targeting of acute myeloid leukemia by five-gene engineered T cells expressing transgenic T-cell receptor specific to WT1, chimeric antigenic receptor specific to GM-CSF receptor, bispecific T-cell engager specific to CD33, and tEGFR suicide gene sys

Authors

Institutions

Publication Details

Targeting of acute myeloid leukemia by five-gene engineered T cells expressing transgenic T-cell receptor specific to WT1, chimeric antigenic receptor specific to GM-CSF receptor, bispecific T-cell engager specific to CD33, and tEGFR suicide gene sys

Targeting of acute myeloid leukemia by five-gene engineered T cells expressing transgenic T-cell receptor specific to WT1, chimeric antigenic receptor specific to GM-CSF receptor, bispecific T-cell engager specific to CD33, and tEGFR suicide gene sys

Abstract

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