Optimized Radiosynthesis of the Ketone Body Radioligand (3<i>S</i>)-4-[<sup>18</sup>F]Fluoro-3-hydroxybutyric Acid ([<sup>18</sup>F]FBHB) for PET Imaging
Ketone body imaging using positron emission tomography (PET) provides valuable insights into various pathological conditions, including cancer, neurological disorders, and cardiovascular diseases. While <b>[</b><sup><b>18</b></sup><b>F]FBHB</b> has shown promise as a radiofluorinated ketone body radioligand, its application has been limited by a low-yielding synthesis. Herein, we report an improved radiosynthesis of <b>[</b><sup><b>18</b></sup><b>F]FBHB</b> with a radiochemical yield (RCY) of 21 ± 3%, compared to the original 1.3%. The new methodology streamlines production, enables automation, and expands translational potential.
Authors
- Jenilee D. Woodfield
- Cody Bergman
- Samantha Leier
- Melinda Wuest (ORCID: https://orcid.org/0000-0003-0735-2749)
- Marco Verona
- Frank Wuest (ORCID: https://orcid.org/0000-0002-6705-6450)
- Richard Yuen
Institutions
- College of the Holy Cross (US)
- University of Alberta (CA)
- Cancer Institute (WIA) (IN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1021/acs.orglett.5c02163
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Alberta
- Natural Sciences and Engineering Research Council of Canada