Longitudinal SARS-CoV-2 antibody response in a healthcare worker cohort utilising the Abbott Alinity® anti-nucleocapsid assay
Our study shows low seroprevalence in prior confirmed cases among our HCW population, possibly explained by reduced sensitivity of this assay with increasing time from SARS-CoV-2 exposure and timing of testing. Confirmatory testing with a quantitative assay would help understand the true seroprevalence of SARS-CoV-2 IgG in this cohort.
Authors
- Riya Negi (ORCID: https://orcid.org/0000-0003-3098-2933)
- Sarah Miles (ORCID: https://orcid.org/0000-0002-9728-7428)
- Lee Graham (ORCID: https://orcid.org/0000-0001-7592-8880)
- Patrick Mallon (ORCID: https://orcid.org/0000-0002-4337-6222)
- Sandra Green
- Peter O’Gorman
- Dana Alalwan
- A. Léon (ORCID: https://orcid.org/0009-0003-7696-8800)
- Robert Browne (ORCID: https://orcid.org/0000-0003-4092-2328)
- Daragh McGee
- Tara McGinty (ORCID: https://orcid.org/0000-0002-1013-0488)
- Aoife G. Cotter (ORCID: https://orcid.org/0000-0001-7712-3533)
- Stephen P Connolly (ORCID: https://orcid.org/0000-0002-7814-1167)
- Dominick Natin (ORCID: https://orcid.org/0009-0007-3566-0331)
- David Green (ORCID: https://orcid.org/0000-0002-5571-5965)
- Paul Duggan
Institutions
- University College Dublin (IE)
- Mater Misericordiae University Hospital (IE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1371/journal.pone.0325544
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00