Accuracy and Robustness of Bone Volume Fraction Assessment by Photon-Counting, Dual-Energy, and Quantitative CT using Micro-CT as Standard of Reference
Our results highlight the complexity of BV/TV measurements and emphasize the impact of the trabecular bone components on measurement accuracy. Despite these challenges, VMIs from "low" dose PCT provide a reliable alternative to standard QCT. They have the potential to improve the estimation of bone conditions, as well offering valuable insights for clinical, and forensic applications.
Authors
- Philippe K. Zysset (ORCID: https://orcid.org/0000-0002-4712-7047)
- Roy Marcus (ORCID: https://orcid.org/0000-0002-5456-7366)
- Daniel Nanz (ORCID: https://orcid.org/0000-0003-4128-5201)
- Patrik Wili (ORCID: https://orcid.org/0009-0008-4190-4053)
- Alice Dudle (ORCID: https://orcid.org/0000-0001-8929-1454)
- Dominic Gascho (ORCID: https://orcid.org/0000-0001-9004-4362)
- Michael Josef Thali (ORCID: https://orcid.org/0000-0002-2613-6956)
Institutions
- University of Bern (CH)
- University of Zurich (CH)
- Universitätsklinik Balgrist (CH)
Publication Details
- Journal
- Annals of Biomedical Engineering
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1007/s10439-025-03732-z
- Citations
- 3
- Primary Topic
- Advanced X-ray and CT Imaging
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- Universität Zürich