Bavachin ameliorates cisplatin-induced nephrotoxicity by enhancing mitochondrial β-oxidation and lipid metabolism through MFN2
This study is the first to confirm MFN2 as a target for renal protection by bavachin. Mechanistically, Bavachin alleviated cisplatin-induced lipid accumulation and apoptosis by upregulating MFN2 expression, which activated CPT1a to promote mitochondrial FAO. These results will provide a new strategy for cisplatin-based cancer therapy and the reduction of its nephrotoxicity.
Authors
- Ming Yang (ORCID: https://orcid.org/0000-0002-7735-7804)
- Lin Sun (ORCID: https://orcid.org/0000-0002-4544-0822)
- Chenrui Li (ORCID: https://orcid.org/0000-0001-8997-6293)
- Shilu Luo
- Yan Liu (ORCID: https://orcid.org/0000-0002-3961-9172)
- Na Jiang (ORCID: https://orcid.org/0000-0003-4156-4737)
Institutions
- Central South University (CN)
- Hunan University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Hunan Institute of Microbiology (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s10020-025-01283-6
- Citations
- 4
- Primary Topic
- Chemotherapy-induced organ toxicity mitigation
- Type
- article
- Field-Weighted Citation Impact
- 5.89