A liquid biopsy approach detects HCC and identifies GJA4 as a potential biomarker for HBV-HCC via plasma cfDNA methylome profiling
This study provides biomarkers for detecting, staging and early detection of HCC using plasma cfDNA methylome profiling. Additionally, the dynamic alteration of GJA4 promoter methylation may serve as a molecular clue for studying HBV-related HCC carcinogenesis and prognosis.
Authors
- Yuanke Pan
- Jinxin Zhu (ORCID: https://orcid.org/0000-0002-3248-7410)
- Bingding Huang (ORCID: https://orcid.org/0000-0002-4748-2882)
- Jialing Sun (ORCID: https://orcid.org/0000-0002-0227-6364)
- Xinfeng Sun
- Ruyun Ruan (ORCID: https://orcid.org/0009-0004-6849-8121)
- Rui Hu (ORCID: https://orcid.org/0000-0002-9765-9922)
- Mingji Feng
- Minling Lv
- Zhiyi Han
- Wenxing Feng
- Jing Li (ORCID: https://orcid.org/0000-0002-0319-9700)
- Wei Zhang (ORCID: https://orcid.org/0000-0001-6911-0900)
- Jinyu Yi
- Xiaozhou Zhou (ORCID: https://orcid.org/0000-0002-4758-0060)
- Xin Zhong (ORCID: https://orcid.org/0000-0001-9944-0484)
- Qi Huang (ORCID: https://orcid.org/0000-0001-6726-6434)
- Weihuang He
- Pin Cui
- Mengqing Ma (ORCID: https://orcid.org/0000-0003-4402-7988)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Beike Biotechnology (China) (CN)
- Shenzhen Technology University (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s13148-025-01909-w
- Citations
- 2
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- National Natural Science Foundation of China