Conversion surgery following severe cytokine release syndrome induced by immune checkpoint inhibitors doublet in advanced hepatocellular carcinoma
CRS is a potentially severe irAE that may also signal favorable immune activation. Early recognition and appropriate management of CRS are essential, and in select cases, ICI-induced CRS may facilitate curative conversion surgery in advanced HCC.
Authors
- Hiromitsu Maehira (ORCID: https://orcid.org/0000-0003-3064-5216)
- Toru Miyake (ORCID: https://orcid.org/0000-0003-0947-0116)
- Haruki Mori (ORCID: https://orcid.org/0000-0001-9143-256X)
- Sachiko Kaida (ORCID: https://orcid.org/0000-0002-1279-5942)
- Masaji Tani (ORCID: https://orcid.org/0000-0003-1270-6003)
- Yusuke Nishina
- Katsushi Takebayashi
- M. Kojima (ORCID: https://orcid.org/0000-0002-1044-6212)
- Nobuhito Nitta
- Hajime Ishikawa
Institutions
- Shiga University of Medical Science (JP)
Publication Details
- Journal
- Clinical Journal of Gastroenterology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1007/s12328-025-02155-6
- Citations
- 1
- Primary Topic
- CAR-T cell therapy research
- Type
- article
- Field-Weighted Citation Impact
- 1.05