Genome-wide meta-analysis identifies nine loci associated with higher risk of hepatocellular carcinoma development
The genetic underpinnings of HCC remain largely unknown. In this genome-wide association meta-analysis totaling 6,540 cases with HCC and 2.1 million controls, we identified and validated nine genetic loci to associate with the risk of HCC. A deeper insight into genetic factors that affect the risk of HCC could improve our ability to predict and ultimately prevent or treat this deadly cancer.
Authors
- Mie Topholm Bruun (ORCID: https://orcid.org/0000-0002-8819-5388)
- Christina Mikkelsen (ORCID: https://orcid.org/0000-0002-2945-6197)
- Helene Gellert‐Kristensen (ORCID: https://orcid.org/0000-0002-9771-9876)
- Søren Brunak (ORCID: https://orcid.org/0000-0003-0316-5866)
- Søren A Rand (ORCID: https://orcid.org/0000-0002-1892-1911)
- Henrik Ullum (ORCID: https://orcid.org/0000-0001-7306-9058)
- Colm J. O’Rourke (ORCID: https://orcid.org/0000-0002-2224-2663)
- Kāri Stefánsson (ORCID: https://orcid.org/0000-0003-1676-864X)
- Anne-Sofie Seidelin
- Pia R. Lundegaard (ORCID: https://orcid.org/0000-0002-8284-1844)
- Jesper B. Andersen (ORCID: https://orcid.org/0000-0003-1760-5244)
- Hans‐Christian Pommergaard (ORCID: https://orcid.org/0000-0001-7068-1946)
- Lincoln Nadauld (ORCID: https://orcid.org/0000-0002-1935-4998)
- Triin Laisk (ORCID: https://orcid.org/0000-0003-1501-9030)
- Daníel F. Guðbjartsson (ORCID: https://orcid.org/0000-0002-5222-9857)
- Gustav Ahlberg (ORCID: https://orcid.org/0000-0003-0066-2779)
- Chigoziri Konkwo (ORCID: https://orcid.org/0000-0001-9082-7498)
- Jakob Thaning Bay (ORCID: https://orcid.org/0000-0003-1159-4003)
- Henning Bundgaard (ORCID: https://orcid.org/0000-0002-0563-7049)
- Johan Skov Bundgaard (ORCID: https://orcid.org/0000-0003-2069-9034)
- Ole Birger Pedersen (ORCID: https://orcid.org/0000-0003-2312-5976)
- Jonas Ghouse (ORCID: https://orcid.org/0000-0002-9634-5964)
- Sisse Rye Ostrowski (ORCID: https://orcid.org/0000-0001-5288-3851)
- Karina Banasik (ORCID: https://orcid.org/0000-0003-2489-2499)
- Þórunn Rafnar (ORCID: https://orcid.org/0000-0003-0491-7046)
- Patrick Sulem (ORCID: https://orcid.org/0000-0001-7123-6123)
- Bitten Aagaard (ORCID: https://orcid.org/0000-0001-8306-1332)
- Reedik Mägi (ORCID: https://orcid.org/0000-0002-2964-6011)
- Magnús Ö. Úlfarsson (ORCID: https://orcid.org/0000-0002-0461-040X)
- Khoa Manh Dinh (ORCID: https://orcid.org/0000-0003-1881-5673)
- Christian Erikstrup (ORCID: https://orcid.org/0000-0001-6551-6647)
- Ulrik Lassen (ORCID: https://orcid.org/0000-0002-3865-4574)
- Einar Stefan Bjornsson (ORCID: https://orcid.org/0000-0002-8392-0632)
- Vinicius Tragante (ORCID: https://orcid.org/0000-0002-8223-8957)
- Sílvia Vilarinho (ORCID: https://orcid.org/0000-0002-2099-4212)
- Joseph Brancale (ORCID: https://orcid.org/0000-0002-1948-5103)
- Hilma Hólm (ORCID: https://orcid.org/0000-0002-9517-6636)
- Stacey Knight (ORCID: https://orcid.org/0000-0003-0092-7327)
- Kirk U. Knowlton (ORCID: https://orcid.org/0000-0003-3544-4130)
- Stefan Stender (ORCID: https://orcid.org/0000-0003-0281-5900)
- Garðar Sveinbjörnsson (ORCID: https://orcid.org/0000-0003-2429-9468)
- Tim Møller Eyrich
- Gudmar Thorleifsson
- Jens Hillingsø
- Erik Sørensen
- Kirsten Vistisen
- Lise Lotte Gluud (ORCID: https://orcid.org/0000-0002-9462-4468)
- Jacob Træholt
Institutions
- Statens Serum Institut (DK)
- Intermountain Healthcare (US)
- University of Copenhagen (DK)
- deCODE Genetics (Iceland) (IS)
- University of Iceland (IS)
- Aalborg University Hospital (DK)
- Novo Nordisk Foundation (DK)
- Odense University Hospital (DK)
- Hvidovre Hospital (DK)
- Aarhus University Hospital (DK)
- Copenhagen University Hospital (DK)
- Gentofte Hospital (DK)
- Rigshospitalet (DK)
- Yale University (US)
- National University Hospital of Iceland (IS)
- Zealand University Hospital Køge (DK)
- University of Tartu (EE)
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101485
- Citations
- 6
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.13
Funders
- Arvid Nilssons Fond
- Innovationsfonden
- European Commission
- Eesti Teadusagentuur
- Gentofte Hospital
- Novo Nordisk
- NordForsk
- Rigshospitalet
- Tartu Ülikool
- Novo Nordisk Fonden
- Villadsen Family Foundation
- National Institutes of Health
- European Regional Development Fund
- National Institute of Diabetes and Digestive and Kidney Diseases