Epigenetic Heritability of Cell Plasticity Drives Cancer Drug Resistance through a One-to-Many Genotype-to-Phenotype Paradigm
Drug resistance is driven by genetic-epigenetic memory that enables cancer cells to adopt multiple phenotypic states depending on environmental conditions, supporting integration of evolutionary principles into biomarker discovery and personalized treatment strategies. This article is part of a special series: Driving Cancer Discoveries with Computational Research, Data Science, and Machine Learning/AI.
Authors
- Inmaculada Spiteri (ORCID: https://orcid.org/0000-0002-1097-8972)
- Andrea Bertotti (ORCID: https://orcid.org/0000-0001-8196-7608)
- Luca Magnani (ORCID: https://orcid.org/0000-0002-7534-0785)
- Giulio Caravagna (ORCID: https://orcid.org/0000-0003-4240-3265)
- Trevor A. Graham (ORCID: https://orcid.org/0000-0001-9582-1597)
- Andrea Sottoriva (ORCID: https://orcid.org/0000-0001-6709-9533)
- Erika Yara-Romero (ORCID: https://orcid.org/0009-0002-7557-9128)
- Gianluca Ascolani (ORCID: https://orcid.org/0000-0001-5501-3368)
- Georgios Vlachogiannis (ORCID: https://orcid.org/0000-0003-3114-8772)
- Lucrezia Patruno (ORCID: https://orcid.org/0000-0002-3721-9984)
- Érica A. Oliveira (ORCID: https://orcid.org/0000-0002-1624-4021)
- Alex Graudenzi (ORCID: https://orcid.org/0000-0001-5452-1918)
- Timon Heide (ORCID: https://orcid.org/0000-0002-1386-7469)
- George D. Cresswell (ORCID: https://orcid.org/0000-0003-3303-068X)
- Salvatore Milite (ORCID: https://orcid.org/0000-0002-0156-3636)
- Ahmet Acar (ORCID: https://orcid.org/0000-0002-2478-8029)
- Chela James (ORCID: https://orcid.org/0000-0003-3996-0909)
- Nicola Valeri (ORCID: https://orcid.org/0000-0002-5426-5683)
- Javier Fernández-Mateos (ORCID: https://orcid.org/0000-0002-4949-4131)
- Bingjie Chen (ORCID: https://orcid.org/0000-0001-7689-2146)
Institutions
- University of Trieste (IT)
- Institute of Cancer Research (GB)
- Middle East Technical University (TR)
- Breast Cancer Now (GB)
- 5T Torino (Italy) (IT)
- Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality (CN)
- Cambridge University Health Partners (GB)
- Human Technopole (IT)
- St Anna Children's Hospital (AT)
- Candiolo Cancer Institute (IT)
- St. Anna Children's Cancer Research Institute
- Imperial College London (GB)
- University of Turin (IT)
- University of Milano-Bicocca (IT)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Research
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1158/0008-5472.can-25-0999
- Citations
- 6
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Wellcome Trust
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- Cancer Research UK
- National Institute for Health and Care Research
- Associazione Italiana per la Ricerca sul Cancro
- Servier