DNA methylation patterns in breast cancer, paired benign tissue from ipsilateral and contralateral breast, and healthy controls
DNA methylation profiles differ profoundly at two points: tumor to case-benign and case-benign to HDB, with clear distinction between ER + and ER- tumors. Case-benign tissues are not epigenetically "normal", are similar across both breasts, and do not differ by ER status of paired tumors.
Authors
- Susan Clare
- Wanding Zhou (ORCID: https://orcid.org/0000-0001-9126-1932)
- Mary E. Sehl (ORCID: https://orcid.org/0000-0003-2301-0562)
- Takahiro Tsukioki
- Seema A. Khan (ORCID: https://orcid.org/0000-0002-6307-2023)
- Gannon Cottone
- Saya Dennis (ORCID: https://orcid.org/0000-0003-3887-198X)
- Patricia A. Ganz (ORCID: https://orcid.org/0000-0002-1841-4143)
- Yuan Luo
Institutions
- Northwestern University (US)
- Children's Hospital of Philadelphia (US)
- University of California, Los Angeles (US)
- Okayama University Hospital (JP)
- University of Pennsylvania (US)
Publication Details
- Journal
- Breast Cancer Research
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s13058-025-02057-y
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Northwestern University
- National Institutes of Health
- Robert H. Lurie Comprehensive Cancer Center
- Quest High Performance Computing