Gut Microbiota Modulation through <i>Akkermansia</i> spp <i>.</i> Supplementation Increases CAR T-cell Potency
B-cell lymphoma patients treated with CAR T cells harbor major gut microbiota perturbations and related metabolism that restrain CAR T-cell therapy. Reprogramming the gut microbiota ecosystem by oral A. massiliensis supplementation induces CAR T-cell niching and Tc1 differentiation in the bone marrow, promoting tumor control in an AhR-dependent manner.
Authors
- Laura Creusot (ORCID: https://orcid.org/0000-0002-3882-8423)
- Marine Fidelle (ORCID: https://orcid.org/0000-0002-5589-9688)
- Sylvain Simon (ORCID: https://orcid.org/0000-0001-5985-3946)
- Arnaud Pagès (ORCID: https://orcid.org/0000-0002-2337-8693)
- Myriam Ben Khelil (ORCID: https://orcid.org/0000-0003-4290-4262)
- Romain Daillère
- Adrian Gottschlich (ORCID: https://orcid.org/0000-0002-2898-4182)
- Camille Blériot (ORCID: https://orcid.org/0000-0002-4298-2888)
- Mathilde Bied
- Florent Ginhoux (ORCID: https://orcid.org/0000-0002-2857-7755)
- Peggy Dartigues
- Sebastian Kobold (ORCID: https://orcid.org/0000-0002-5612-4673)
- Alexia Alfaro
- Pierre Ly (ORCID: https://orcid.org/0000-0001-9541-5986)
- Edoardo Pasolli (ORCID: https://orcid.org/0000-0003-0799-3490)
- Nathalie Rolhion (ORCID: https://orcid.org/0000-0002-2946-4808)
- Gladys Ferrere (ORCID: https://orcid.org/0000-0001-6103-9185)
- Camille Bigenwald (ORCID: https://orcid.org/0000-0003-2714-2087)
- Laurie Menger (ORCID: https://orcid.org/0000-0003-0949-6607)
- Harry Sokol (ORCID: https://orcid.org/0000-0002-2914-1822)
- Valentina Petrocelli (ORCID: https://orcid.org/0000-0002-8066-870X)
- Ahmadreza Arbab (ORCID: https://orcid.org/0000-0002-7015-0448)
- Sylvère Durand (ORCID: https://orcid.org/0000-0001-6356-1006)
- Laura Marcos-Kovandzic
- Janesa Srikanthan
- Liwei Zhao (ORCID: https://orcid.org/0000-0001-5077-327X)
- Peng Liu (ORCID: https://orcid.org/0000-0002-1682-9222)
- Michele Avagliano
- Jessica Rengassamy
- Roula Amine-Hneineh
- Rim Abdallah (ORCID: https://orcid.org/0000-0001-5061-5554)
Institutions
- Agency for Science, Technology and Research (SG)
- Centre National de la Recherche Scientifique (FR)
- Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa (ZA)
- Inserm (FR)
- German Cancer Research Center (DE)
- University of Milan (IT)
- Heidelberg University (DE)
- Université Paris-Saclay (FR)
- Singapore Immunology Network (SG)
- Institut Gustave Roussy (FR)
- University Hospital Heidelberg (DE)
- LMU Klinikum (DE)
- Sorbonne Université (FR)
- Fred Hutch Cancer Center (US)
- Centre de Recherche des Cordeliers (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Saint-Antoine (FR)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Fédération Hospitalo-Universitaire, Paris Center for Microbiome Medicine (FR)
- IFOM (IT)
- Centre de Recherche Saint-Antoine (FR)
- Ovarian Cancer Research Alliance (US)
- Bicêtre Hospital (FR)
- Department of Agricultural Sciences (RU)
- Institut Curie (FR)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-1230
- Citations
- 16
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 12.90
Funders
- Gilead Sciences
- Association pour la Recherche sur le Cancer
- Università degli Studi di Milano
- Seerave Foundation
- Equipex
- European Commission
- Deutsche Forschungsgemeinschaft
- Agence Nationale de la Recherche
- Fondation pour la Recherche Médicale
- Ligue Contre le Cancer
- Institut Universitaire de France
- Associazione Italiana per la Ricerca sul Cancro
- Institut National Du Cancer
- Servier
- Université de Paris
- Institut Servier
- HORIZON EUROPE Framework Programme
- Labex Immuno-Oncology