Gram-negative intratumoral bacteria mediate lymph node metastasis through LPS-TLR4/MAPK signaling pathway in cervical cancer
The study suggests that Gram-negative bacteria, particularly E. coli, P. bivia, and F. nucleatum, play a causal role in exacerbating lymph node metastasis in CC. These findings highlight the potential of targeting these bacteria and their associated signaling pathways as therapeutic strategies to improve clinical outcomes in CC patients.
Authors
- Linhai Li (ORCID: https://orcid.org/0000-0002-5924-905X)
- Chen Fu (ORCID: https://orcid.org/0000-0002-3058-4719)
- Peng Ma (ORCID: https://orcid.org/0000-0003-1611-2974)
- Yongzhu Liu (ORCID: https://orcid.org/0000-0002-9205-3841)
- Weiguo Yin (ORCID: https://orcid.org/0000-0002-1318-9688)
- Lunhao Yang
- Lu Yang (ORCID: https://orcid.org/0009-0003-8948-1882)
- Dongdong Liu (ORCID: https://orcid.org/0000-0002-6172-0832)
- Yaqin Liu (ORCID: https://orcid.org/0000-0002-6982-1849)
- Zhi Hua Ran (ORCID: https://orcid.org/0000-0001-6388-6206)
- Lingqing Xu (ORCID: https://orcid.org/0000-0002-6451-1673)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Panyu Hospital of Chinese Medicine (CN)
- Second Affiliated Hospital of Guangzhou Medical University (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Xiyuan Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Infection
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.jinf.2025.106532
- Citations
- 8
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 7.49
Funders
- Basic and Applied Basic Research Foundation of Guangdong Province