Risk of Ventricular Arrhythmia and Sudden Cardiac Arrest Among Older Patients Using Lamotrigine for Epilepsy
In older adults with epilepsy, lamotrigine was not associated with an increased risk of VA/SCA compared with levetiracetam, including among those with underlying heart disease. Our findings do not support the reported cardiac risks associated with lamotrigine or the recent changes to its safety label.
Authors
- Daniel B. Horton (ORCID: https://orcid.org/0000-0002-1831-1339)
- Tobias Gerhard (ORCID: https://orcid.org/0000-0002-8598-5771)
- Gloria Y. F. Ho (ORCID: https://orcid.org/0000-0002-2045-7070)
- Parin J. Patel (ORCID: https://orcid.org/0000-0002-0500-1059)
- Chintan V. Dave (ORCID: https://orcid.org/0000-0002-7160-9345)
Institutions
- Rutgers, The State University of New Jersey (US)
- Albert Einstein College of Medicine (US)
- Ascension (US)
- Johnson University (US)
- Saint Vincent Health System (US)
Publication Details
- Journal
- Neurology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1212/wnl.0000000000213643
- Citations
- 10
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 14.71