Dysregulation of innate and adaptive lymphoid immunity may have implications for symptom attribution and predict responses to targeted therapies in neuropsychiatric systemic lupus erythematosus
Gene dysregulation patterns related to innate and adaptive lymphoid immunity separated active CNS lupus patients into two distinct subgroups with differential anticipated response to type I interferon, C3, and calcineurin inhibition. Our study provides a conceptual framework for precision medicine in NPSLE and implications for overcoming the major clinical challenge of attributing neuropsychiatric features to SLE versus other causes.
Authors
- Julius Lindblom
- Elena Carnero‐Montoro (ORCID: https://orcid.org/0000-0002-1947-9627)
- Yvonne Enman (ORCID: https://orcid.org/0000-0002-9600-9995)
- Ellen Iacobaeus (ORCID: https://orcid.org/0000-0001-7832-8215)
- Guillermo Barturen (ORCID: https://orcid.org/0000-0003-2103-1028)
- María Orietta Borghi (ORCID: https://orcid.org/0000-0001-8967-9678)
- Daniel Toro‐Domínguez (ORCID: https://orcid.org/0000-0001-8440-312X)
- Lorenzo Beretta (ORCID: https://orcid.org/0000-0002-6529-6258)
- Jéssica Castillo
Institutions
- Karolinska University Hospital (SE)
- Universidad de Granada (ES)
- University of Milan (IT)
- Örebro University (SE)
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (IT)
- Karolinska Institutet (SE)
- IRCCS Istituto Auxologico Italiano (IT)
- Pfizer-University of Granada-Junta de Andalucía Centre for Genomics and Oncological Research (ES)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Houston (US)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100296
- Citations
- 1
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 1.67