Association between Myasthenia Gravis and Smoking
Objective This study investigated the association between smoking and myasthenia gravis (MG), a chronic autoimmune disorder that affects neuromuscular junctions. Methods Data were collected from the Japan MG Registry 2021 survey conducted between April and October 2021. MG severity was assessed using the MG activities of daily living score and MG Foundation of America (MGFA) classification. The Brinkman Index, calculated as the number of cigarettes smoked per day multiplied by the number of years smoked, was used to evaluate the correlation between smoking exposure and MG severity. We also compared the smoking rates of individuals with and without MG stratified by age and sex. Results Of the 1,402 patients selected from the Japanese registry, higher smoking rates were observed in patients with MG than in the general population. Compared with never-smokers, women with MG who smoked were younger and had a higher prevalence of ocular symptoms. A weak correlation was observed between MGFA and Brinkman indices among men with MG who smoked. No correlation was observed between smoking status and MG severity in women who smoked. Conclusion This study utilized one of the largest datasets on MG and smoking; thus, it provides valuable insights into the association between smoking and MG.
Authors
- Akiyuki Uzawa (ORCID: https://orcid.org/0000-0001-9252-1863)
- Kimiaki Utsugisawa (ORCID: https://orcid.org/0000-0001-9373-8167)
- Satoshi Kuwabara (ORCID: https://orcid.org/0000-0002-4716-8578)
- Naoki Kawaguchi (ORCID: https://orcid.org/0009-0001-3872-857X)
- Masayuki Masuda (ORCID: https://orcid.org/0000-0002-6175-8902)
- Hiroyuki Akamine (ORCID: https://orcid.org/0000-0002-4041-1635)
- Genya Watanabe (ORCID: https://orcid.org/0000-0001-8444-6525)
- Tomoya Kubota (ORCID: https://orcid.org/0000-0003-1004-8537)
- Yosuke Onishi
- Manato Yasuda (ORCID: https://orcid.org/0000-0002-2876-3857)
- Naoya Minami (ORCID: https://orcid.org/0009-0002-4971-9609)
- Shingo Konno (ORCID: https://orcid.org/0000-0002-8731-0663)
- Takashi Kimura (ORCID: https://orcid.org/0000-0002-0401-7227)
- Yuriko Nagane (ORCID: https://orcid.org/0000-0003-2464-8947)
- Yukiko Ozawa (ORCID: https://orcid.org/0000-0002-2586-6949)
- Takamichi Sugimoto (ORCID: https://orcid.org/0000-0003-3652-0772)
- Makoto Samukawa (ORCID: https://orcid.org/0000-0003-3464-0754)
- Masanori Takahashi (ORCID: https://orcid.org/0000-0002-5513-5012)
- Yasushi Suzuki (ORCID: https://orcid.org/0000-0002-1952-9604)
- Shigeaki Suzuki
Institutions
- Hiroshima University (JP)
- Toho University (JP)
- Tokyo Medical University (JP)
- Chiba University (JP)
- Keio University (JP)
- Toho University Ohashi Medical Center (JP)
- National Hospital Organization Hokkaido Medical Center (JP)
- Sendai Medical Center (JP)
- Tokyo Metropolitan Neurological Hospital (JP)
- National Hospital Organization Hanamaki Hospital (JP)
- Chiba Hospital (JP)
- National Hospital Organization (JP)
- University of the Ryukyus University Hospital (JP)
- Hyogo University (JP)
- Kindai University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Internal Medicine
- Published
- 2025-06-11
- DOI
- https://doi.org/10.2169/internalmedicine.5310-25
- Primary Topic
- Myasthenia Gravis and Thymoma
- Type
- article
- Field-Weighted Citation Impact
- 0.00