Validation of a Computational Fluid Dynamics-Based Fractional Flow Reserve Estimation Method Using Vascular Volume Ratio from Coronary Computer Tomography

Background: Fractional flow reserve (FFR) is the gold standard for invasive assessment of myocardial ischemia in the diagnosis of coronary artery disease (CAD). Traditionally, FFR is measured using pressure wires during coronary angiography. Recently, computational fluid dynamics (CFD) has been applied to calculate FFR noninvasively and efficiently. However, conventional CFD methods often require complex computations. This study aimed to evaluate simplified analytical conditions for CFD-based FFR calculations.