Disruption of ventricular activation by subthreshold delayed afterdepolarizations in RyR2-R420Q catecholaminergic polymorphic ventricular tachycardia
Increased activation dispersion could arise from subthreshold DADs in R420Q mouse hearts and may contribute to conduction block. This could increase the propensity for re-entrant arrhythmias in CPVT without directly triggering ectopic beats.
Authors
- Ewan D. Fowler (ORCID: https://orcid.org/0000-0001-5580-2156)
- S Diakite
- Ana M. Gómez (ORCID: https://orcid.org/0000-0003-0009-2884)
- Michael A. Colman (ORCID: https://orcid.org/0000-0003-2817-8508)
Institutions
- University of Leeds (GB)
- Inserm (FR)
- Université Paris-Saclay (FR)
- Laboratory Signaling and Cardiovascular Pathophysiology (FR)
- Cardiff University (GB)
Publication Details
- Journal
- Journal of Molecular and Cellular Cardiology Plus
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.jmccpl.2025.100466
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 0.00