Endothelial cell source dictates the expression and release of fibrinolytic markers in a proinflammatory environment
HCAECs respond more potently to a proinflammatory environment than HUVECs, altering expression of fibrinolytic proteins and promoting a hypofibrinolytic response. These data highlight HCAECs as a model of coronary vasculature with potential for screening novel antithrombotic strategies.
Authors
- Steven J. Humphreys (ORCID: https://orcid.org/0000-0001-8315-116X)
- Nicola J. Mutch (ORCID: https://orcid.org/0000-0002-7452-0813)
- Claire S. Whyte (ORCID: https://orcid.org/0000-0001-8127-6102)
Institutions
- University of Aberdeen (GB)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.rpth.2025.102929
- Citations
- 1
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- British Heart Foundation
- National Centre for the Replacement, Refinement and Reduction of Animals in Research
- Friends of ANCHOR