SAE1 emerges as a pan-cancer driver and key regulator of HCC metastasis
This study established SAE1 as a novel independent prognostic biomarker in multiple cancers and identified its mechanistic role in HCC progression, suggesting its potential value for future translational research toward therapeutic development.
Authors
- Feng Han (ORCID: https://orcid.org/0009-0002-7449-6750)
- Xiao Sun (ORCID: https://orcid.org/0000-0003-3935-4255)
- Guanchen Liu (ORCID: https://orcid.org/0000-0002-9930-0243)
- Xuda Ma
- Tingting Zhang (ORCID: https://orcid.org/0000-0002-1919-1471)
- Chuan Dong (ORCID: https://orcid.org/0000-0002-6291-8357)
- Yamei Dang (ORCID: https://orcid.org/0000-0002-8114-0915)
- Shujie Zhai
- Li Sun (ORCID: https://orcid.org/0000-0003-3069-6224)
- Hao Zhuang (ORCID: https://orcid.org/0000-0002-7339-8211)
- Yongmei Li (ORCID: https://orcid.org/0000-0003-2625-2006)
- Nanmu Yang
- Wen Wei (ORCID: https://orcid.org/0000-0002-9734-1180)
- Dandan Hong (ORCID: https://orcid.org/0009-0003-9642-6531)
- Xiaowen Shao (ORCID: https://orcid.org/0009-0001-9278-2569)
Institutions
- Zhejiang A & F University (CN)
- Guangdong Medical College (CN)
- Second Hospital of Tianjin Medical University (CN)
- Henan Cancer Hospital (CN)
- Affiliated Hospital of Guangdong Medical College Hospital (CN)
- Arizona State University (US)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.jare.2025.06.028
- Citations
- 1
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.81