A novel peptide MIB1-223aa encoded by exosomal circMIB1 from cancer-associated fibroblasts drives triple-negative breast cancer metastasis and stemness via stabilizing MIB1 to activate Notch signaling
This study provides the first evidence of exosome-transmitted protein-coding circRNAs in CAF-TNBC crosstalk, offering novel insights into the TME-driven metastasis and providing promising biomarker for TNBC management.
Authors
- Jingli Song
- Qifeng Yang (ORCID: https://orcid.org/0000-0003-0576-8513)
- Yuhan Jin (ORCID: https://orcid.org/0000-0002-2887-053X)
- Dianwen Han
- Fangzhou Ye (ORCID: https://orcid.org/0000-0001-9630-2334)
- Yiran Liang (ORCID: https://orcid.org/0000-0002-2404-0408)
- Lei Wang (ORCID: https://orcid.org/0000-0001-5024-0238)
- Bing Chen (ORCID: https://orcid.org/0000-0003-0168-8532)
- Xiaoyan Li (ORCID: https://orcid.org/0000-0003-1910-2464)
- Tong Chen (ORCID: https://orcid.org/0000-0001-7895-2077)
- Yaming Li (ORCID: https://orcid.org/0000-0001-5627-229X)
- Jianing Wang (ORCID: https://orcid.org/0000-0001-6939-5029)
- Dan Luo (ORCID: https://orcid.org/0000-0003-2250-8705)
- Wenjing Zhao (ORCID: https://orcid.org/0000-0003-4477-596X)
- Lijuan Wang (ORCID: https://orcid.org/0000-0002-7728-9282)
Institutions
- Taian City Central Hospital (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.jare.2025.06.023
- Citations
- 9
- Primary Topic
- Circular RNAs in diseases
- Type
- article
- Field-Weighted Citation Impact
- 7.25