Improved tumor-type informed compared to tumor-informed mutation tracking for ctDNA detection and microscopic residual disease assessment in epithelial ovarian cancer
The tumor-type informed classifier demonstrated sensitivity and specificity for ctDNA detection, outperforming the tumor-informed approach in monitoring EOC progression. Requiring fewer sequencing data, it offers a practical, efficient solution for clinical management of EOC.
Authors
- Louise Benoit (ORCID: https://orcid.org/0000-0002-0871-1793)
- Valérie Taly (ORCID: https://orcid.org/0000-0002-3116-8602)
- Aurélien de Reyniès (ORCID: https://orcid.org/0000-0002-1328-5290)
- Bruno Borghese (ORCID: https://orcid.org/0000-0002-6385-5829)
- Charles Marcaillou
- Sylvain Guibert
- Anne‐Sophie Bats (ORCID: https://orcid.org/0000-0001-5333-3296)
- Jacques Médioni (ORCID: https://orcid.org/0000-0003-1100-5264)
- Henri Azaïs (ORCID: https://orcid.org/0000-0002-6855-9754)
- Emmanuel Martin (ORCID: https://orcid.org/0000-0003-4211-7373)
- Maria Paola Sassi (ORCID: https://orcid.org/0000-0002-6730-6544)
- Pierre Laurent‐Puig (ORCID: https://orcid.org/0000-0001-8475-5459)
- Jérôme Alexandre (ORCID: https://orcid.org/0000-0001-5252-5800)
- E.A. Laude
- Cam Duong
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Centre de Recherche des Cordeliers (FR)
- Hôpital Cochin (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Groupe Hospitalier Cochin - Port-Royal, Hôtel-Dieu, Broca - La Collégiale (FR)
- IntegraGen (France) (FR)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s13046-025-03433-4
- Citations
- 1
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- Association Nationale de la Recherche et de la Technologie
- Institute of Cancer Research