<i>Setd1a</i> Loss-of-function Disrupts Epigenetic Regulation of Ribosomal Genes via Altered DNA Methylation
Our findings suggest that SETD1A haploinsufficiency disrupts the epigenetic regulation of ribosomal pathways. These results provide insight into an alternative mechanism through which genetic variation in SETD1A influences developmental and synaptic plasticity, contributing to schizophrenia pathophysiology.
Authors
- Nicholas E. Clifton (ORCID: https://orcid.org/0000-0003-2597-5253)
- Eilis J. Hannon (ORCID: https://orcid.org/0000-0001-6840-072X)
- Joe Burrage (ORCID: https://orcid.org/0009-0002-1567-713X)
- Isabel Castanho (ORCID: https://orcid.org/0000-0003-1413-626X)
- Stefania S S Policicchio
- Kirtikesav Salem Saravanaraj
- Jonathan S. Mill (ORCID: https://orcid.org/0000-0003-1115-3224)
- Matthew L. Bosworth (ORCID: https://orcid.org/0000-0003-1391-7515)
- Anthony R Isles (ORCID: https://orcid.org/0000-0002-7587-5712)
- Emma Louise Dempster (ORCID: https://orcid.org/0000-0003-1257-5314)
- Emma Walker (ORCID: https://orcid.org/0000-0003-2222-4577)
- Jeremy Hall
Institutions
- University of Exeter (GB)
- Health & Life (Taiwan) (TW)
- Cardiff University (GB)
Publication Details
- Journal
- Schizophrenia Bulletin
- Published
- 2025-05-14
- DOI
- https://doi.org/10.1093/schbul/sbaf091
- Citations
- 4
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- Wellcome Trust
- Waterloo Foundation
- Medical Research Council