Radiogenomic correlation of hypoxia-related biomarkers in clear cell renal cell carcinoma
The RF model demonstrated modest but significant associations between texture metrics derived from clinical CT scans, such as GLDM and GLCM, and key hypoxia-related biomarkers including KLF6, BCL2, ETS1, and PLOD2. These findings suggest that radiomic analysis could support ccRCC risk stratification and personalized treatment planning by providing non-invasive insights into tumor biology.
Authors
- Vinay Duddalwar (ORCID: https://orcid.org/0000-0002-4808-5715)
- Inderbir S. Gill (ORCID: https://orcid.org/0000-0002-5113-7846)
- S J Pawan
- Harmony Cen
- Yijun Shao (ORCID: https://orcid.org/0000-0001-6419-7963)
- Anishka D'souza
- Xiaomeng Lei
- Anu Dhananjay
Institutions
- University of Southern California (US)
- Los Angeles Medical Center (US)
- Bellevue Hospital Center (US)
Publication Details
- Journal
- Journal of Cancer Research and Clinical Oncology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1007/s00432-025-06240-8
- Citations
- 3
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56
Funders
- University of Southern California