Phosphate-driven microstructural evolution of hydroxyapatite
The microstructure, composition, and size of hydroxyapatite (HA) are key factors influencing its physicochemical properties and potential applications. However, research on the impact of the intrinsic physicochemical properties of phosphates on the HA microstructure remains limited. Herein, one-dimensional (1D) HA nanofibers and three-dimensional (3D) microspheres were successfully synthesized using ricinoleic acid-assisted solvothermal synthesis with three different phosphate sources (NaH<sub>2</sub>PO<sub>4</sub>·2H<sub>2</sub>O, Na<sub>5</sub>P<sub>3</sub>O<sub>10</sub>, and (NaPO<sub>3</sub>)<sub>6</sub>). XRD, SEM, and TEM analyses revealed that NaH<sub>2</sub>PO<sub>4</sub>·2H<sub>2</sub>O favors the formation of ultralong flexible HA nanofibers that preferentially grow along the <i>c</i>-axis, whereas (NaPO<sub>3</sub>)<sub>6</sub> inhibits <i>c</i>-axis growth and promotes the formation of nanorod self-assembled microspheres. Based on these findings, a mechanism was proposed to explain the phosphate-mediated regulation of HA microstructural evolution from 1D nanofibers to 3D microspheres.
Authors
- Jianfeng Qiu (ORCID: https://orcid.org/0000-0002-8049-3743)
- Gui‐yong Xiao
- Meng Zhang (ORCID: https://orcid.org/0009-0008-4457-5494)
- Linmao Ma
- Hongjin Xue (ORCID: https://orcid.org/0000-0001-6606-8006)
- Yinchuan Wang (ORCID: https://orcid.org/0000-0001-5919-2551)
- Yu-Peng Lu
Institutions
- Shandong University (CN)
- Affiliated Hospital of Taishan Medical University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Dalton Transactions
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5dt00991j
- Citations
- 3
- Primary Topic
- Bone Tissue Engineering Materials
- Type
- article
- Field-Weighted Citation Impact
- 2.02
Funders
- Natural Science Foundation of Shandong Province
- Key Technology Research and Development Program of Shandong