Integrative multi-omics profiling deciphers tumor microenvironment heterogeneity and immunotherapy vulnerabilities in lung neuroendocrine carcinomas
This study advances the understanding of the tumor immune microenvironment in Lu-NECs through multi-omics characterization and highlights potential personalized therapeutic vulnerabilities tailored to the specific immune landscapes of Lu-NECs.
Authors
- Siqi Bao (ORCID: https://orcid.org/0000-0003-3885-125X)
- Meng Zhou (ORCID: https://orcid.org/0000-0001-9987-9024)
- Bingning Wang (ORCID: https://orcid.org/0009-0007-7748-7098)
- Fan Yang (ORCID: https://orcid.org/0000-0003-3106-7593)
- Xujie Sun
- Modi Zhai
- Ruanqi Chen
- Lin Yang (ORCID: https://orcid.org/0000-0001-5383-4779)
- Zicheng Zhang
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Wenzhou Medical University (CN)
- National Cancer Center (US)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.jare.2025.06.017
- Citations
- 6
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.27