Genomic Analysis of Multidrug Resistant <i>Enterobacter hormaechei</i> Strain AH1-NIMR Isolated from a Neonate with Sepsis in Lagos, Nigeria
<i>Enterobacter hormaechei</i> has emerged as a major bacterial pathogen implicated in neonatal sepsis, with several strains acquiring resistance to commonly used antibiotics. In this study, we provide the antibiotic resistance profile and genomic analysis of a multidrug-resistant <i>E. hormaechei</i> AH1-NIMR isolated from a neonate presenting with sepsis in a tertiary hospital in Lagos, Nigeria. <i>E. hormaechei</i> AH1-NIMR was resistant to ten of twelve antibiotics that were tested. Whole-genome sequencing and bioinformatics analysis revealed that the isolate harboured several antimicrobial resistance determinants, including plasmids IncHI2-1 and Col(pHAD28). Enhanced surveillance and screening for <i>E. hormaechei</i> in sepsis cases are recommended.
Authors
- A. Seriki (ORCID: https://orcid.org/0000-0001-9406-3691)
- Utibeima Udo Essiet (ORCID: https://orcid.org/0000-0003-0422-8689)
- Stella Smith (ORCID: https://orcid.org/0000-0003-2163-1189)
- Abraham Ajayi (ORCID: https://orcid.org/0000-0001-6681-1795)
- Tenny Obiageli Gladys Egwuatu (ORCID: https://orcid.org/0000-0002-4878-5551)
- Chioma Obi (ORCID: https://orcid.org/0000-0002-3377-5115)
- Desmond Wemimo Akingboye (ORCID: https://orcid.org/0009-0009-4260-7728)
- Amusa Azeez Olashile (ORCID: https://orcid.org/0009-0007-8777-8577)
Institutions
- Lagos State University (NG)
- Bells University of Technology (NG)
- University of Lagos (NG)
- Lagos State University of Science and Technology (NG)
- Mountain Top University (NG)
- Nigerian Institute of Medical Research (NG)
Publication Details
- Journal
- Infection and Chemotherapy
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3947/ic.2025.0040
- Citations
- 2
- Primary Topic
- Enterobacteriaceae and Cronobacter Research
- Type
- article
- Field-Weighted Citation Impact
- 3.60