A positive correlation between the pseudorotational phase angle <i>P</i> and the δ <sub>H</sub> torsion angle (H4′-C4′-C3′-H3′) in nucleosides and nucleic acids
Examination of structures of DNA duplexes (A-, B-, and Z-DNA) showed a positive correlation between the pseudorotational phase angle <i>P</i> and the torsion angle δ<sub>H</sub> (H4'-C4'-C3'-H3'). Such a <i>P</i> - δ<sub>H</sub> plot reflects the structural features of the three types of DNA duplexes. Since the δ<sub>H</sub> torsion angle can be measured by nuclear magnetic resonance, the linear correlation between <i>P</i> and δ<sub>H</sub> provides a useful method for predicting the sugar pucker of nucleosides and nucleic acids.
Authors
- Hongbin Yan (ORCID: https://orcid.org/0000-0002-9087-0493)
- Aiming Yan (ORCID: https://orcid.org/0000-0002-5394-7498)
- Jesse Vanloon
Institutions
- Brock University (CA)
Publication Details
- Journal
- Nucleosides Nucleotides & Nucleic Acids
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1080/15257770.2025.2516597
- Citations
- 1
- Primary Topic
- DNA and Nucleic Acid Chemistry
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Natural Sciences and Engineering Research Council of Canada