Generation of two novel furanosteroids <i>via</i> heterologous expression of demethoxyviridin biosynthetic genes in a wortmannin-producing strain
Furanosteroids, represented by wortmannin and demethoxyviridin, are a class of structurally unique steroids with significant bioactivities. In this study, wortmannin and its analogue 11-desacetoxywortmannin were isolated from <i>Talaromyces wortmannii</i> ATCC 26942. Subsequently, individual post-tailoring enzyme genes involved in the biosynthesis of demethoxyviridin were introduced into <i>T. wortmannii</i> ATCC 26942, leading to the detection of four putative novel furanosteroids. Among them, two compounds were isolated and identified, both of which are detrimental to <i>Aspergillus niger</i> R330 and <i>Candida albicans</i> FIM709.
Authors
- Linhuan Li
- Wei Jiang (ORCID: https://orcid.org/0000-0001-5518-559X)
- Dan Hu (ORCID: https://orcid.org/0000-0002-1104-8646)
- Lei Zhang (ORCID: https://orcid.org/0000-0001-9798-0268)
- Jian‐Ming Lv (ORCID: https://orcid.org/0000-0002-1185-9342)
- Gao‐Qian Wang (ORCID: https://orcid.org/0009-0002-6943-8564)
- Hao Gao (ORCID: https://orcid.org/0000-0003-1178-0121)
- Guo‐Dong Chen (ORCID: https://orcid.org/0000-0002-6773-4063)
- Huan Zhao
- Shao-Yang Li
Institutions
- Jinan University (CN)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00856e
- Citations
- 1
- Primary Topic
- Viral Infectious Diseases and Gene Expression in Insects
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities