Vascular diameter determines sensitivity to soluble guanylate cyclase activation in human mesenteric and renal arteries
In contrast to murine arteries, SNP- and cinaciguat-induced vasodilation is similar in human intrarenal and mesenteric arteries. In the human vasculature, small diameter arteries are more responsive to sGC activation than large diameter vessels irrespective of the degree of MLC<sub>20</sub>-S19 phosphorylation.
Authors
- Kangbo Li (ORCID: https://orcid.org/0000-0003-0186-3265)
- Jürgen Hescheler
- Simon Jasinski‐Bergner (ORCID: https://orcid.org/0000-0001-6300-7371)
- Vladimir Todorov (ORCID: https://orcid.org/0000-0002-7011-8130)
- Hendrik Borgmann (ORCID: https://orcid.org/0000-0002-3955-564X)
- Thomas Enzmann
- Doris Metzler
- Gabriele Pfitzer (ORCID: https://orcid.org/0000-0002-8684-8947)
- Olaf Grisk (ORCID: https://orcid.org/0000-0001-6842-1256)
- Tatiana Korotkova (ORCID: https://orcid.org/0000-0001-7964-9838)
- Lubomir T. Lubomirov (ORCID: https://orcid.org/0000-0002-3854-7170)
- René Mantke (ORCID: https://orcid.org/0000-0001-5590-6019)
Institutions
- Witten/Herdecke University (DE)
- University of Cologne (DE)
- Medizinische Hochschule Brandenburg Theodor Fontane (DE)
- Universitätsklinikum Brandenburg an der Havel (DE)
- University Hospital Carl Gustav Carus (DE)
Publication Details
- Journal
- Vascular Pharmacology
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1016/j.vph.2025.107515
- Citations
- 2
- Primary Topic
- Renin-Angiotensin System Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.78