<i>Helicobacter pylori</i> CagA protein is a potent and broad-spectrum amyloid inhibitor
Bacteria, the smallest and most abundant life forms on Earth, have been a source of insights that have had a considerable impact on human health. <i>Helicobacter pylori</i> has captured substantial attention due to its role in provoking an array of gastrointestinal ailments and other human diseases. Here, we report that <i>H. pylori</i> releases the protein CagA (cytotoxin-associated gene A) that strongly inhibits formation of both functional (bacterial biofilm) and pathogenic amyloid assemblies by targeting various stages during fibril formation. CagA's broad substrate specificity reveals a mechanism whereby <i>H. pylori</i> interferes with other bacteria and humans, offering approaches to combat bacterial infections and human protein misfolding diseases.
Authors
- Cecilia Mörman (ORCID: https://orcid.org/0000-0003-4464-1769)
- Axel Leppert (ORCID: https://orcid.org/0000-0001-6223-3350)
- Stefan D. Knight (ORCID: https://orcid.org/0000-0002-7180-8758)
- Olena Moshynets (ORCID: https://orcid.org/0000-0002-2209-8681)
- Andreas Møllebjerg (ORCID: https://orcid.org/0000-0001-6633-6939)
- Gefei Chen (ORCID: https://orcid.org/0000-0002-5543-5963)
- Jan Johansson (ORCID: https://orcid.org/0000-0002-8719-4703)
- M. S. Frasinyuk
- William P. Olsen (ORCID: https://orcid.org/0000-0002-5603-8310)
- Daniel Ferreira (ORCID: https://orcid.org/0000-0001-9522-4338)
- Axel Abelein (ORCID: https://orcid.org/0000-0002-8079-3017)
- Daniel E. Otzen (ORCID: https://orcid.org/0000-0002-2918-8989)
- Rakesh Kumar (ORCID: https://orcid.org/0000-0003-2029-8687)
- Zhen Jin
- Lotte B. Nielsen (ORCID: https://orcid.org/0000-0003-2166-7560)
- Michael Landreh (ORCID: https://orcid.org/0000-0002-7958-4074)
- Jokin Yeregui Elosua
Institutions
- Uppsala University (SE)
- Aarhus University (DK)
- Paul Scherrer Institute (CH)
- Karolinska Institutet (SE)
- Universidad Fernando Pessoa Canarias (ES)
- Integrated Cardio Metabolic Centre (SE)
- Institute of Bioorganic Chemistry and Petrochemistry V.P. Kukhar (UA)
- Institute of Molecular Biology and Genetics (UA)
Publication Details
- Journal
- Science Advances
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1126/sciadv.ads7525
- Citations
- 2
- Primary Topic
- Helicobacter pylori-related gastroenterology studies
- Type
- article
- Field-Weighted Citation Impact
- 4.01