Increased colorectal and endometrial cancer rates in a genomically ascertained Lynch syndrome cohort
NCCN guidelines missed 65% of cases with P/LP LS variants despite families having higher colorectal and endometrial cancer rates compared with controls. Genomic screening can assist in identifying individuals at risk for LS-related cancers, providing an opportunity to tailor risk management for cancer prevention and early detection.
Authors
- Melissa Kelly (ORCID: https://orcid.org/0000-0003-4708-2261)
- Kristy DiLoreto
- H. Lester Kirchner (ORCID: https://orcid.org/0000-0002-2557-6749)
- Juliann M. Savatt (ORCID: https://orcid.org/0000-0001-6444-1962)
- Natasha T. Strande (ORCID: https://orcid.org/0000-0001-5148-9772)
- Miranda L. G. Hallquist (ORCID: https://orcid.org/0000-0001-8554-2447)
- Cameron L Hayes (ORCID: https://orcid.org/0000-0002-0388-5807)
- Adam H. Buchanan (ORCID: https://orcid.org/0000-0002-6518-2453)
- Alicia Johns
- Amie Decker
Institutions
- Geisinger Medical Center (US)
- Genomic Health (United States) (US)
- Geisinger Health System (US)
Publication Details
- Journal
- JNCI Cancer Spectrum
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1093/jncics/pkaf061
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00