Metabolomics-based identification and validation of the creatine precursor guanidinoacetic acid for frailty in older adults
This study identifies GAA as a potential metabolic biomarker for frailty. Higher GAA levels are associated with lower frailty odds and provide predictive value for a lower likelihood of frailty progression.
Authors
- Feng Huang (ORCID: https://orcid.org/0000-0003-4652-4312)
- Xiaoming Huang (ORCID: https://orcid.org/0000-0002-7156-8897)
- Siyang Lin
- Yin Yuan
- Wenwen Lin
- Pengli Zhu (ORCID: https://orcid.org/0000-0001-9619-0723)
Institutions
- Fujian Medical University (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1093/gerona/glaf127
- Primary Topic
- Muscle metabolism and nutrition
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province
- Fujian Provincial Health Commission