Inflammation-associated Lipidomic Signatures Prior to Carotid Artery Atherosclerosis in People Living With HIV
Our findings underscore specific lipidomic-inflammatory networks that may underlie the heightened risk of atherosclerosis in HIV infection. The differential involvement of IL-18 suggests a central role of NLRP3 inflammasome activation in HIV-associated vascular inflammation. The observed alterations in lysophospholipid and short-chain fatty acyl metabolism warrant further mechanistic investigation as potential mediators of HIV-related atherogenesis.
Authors
- Miaochen Wang
- Yunqiu Zhang (ORCID: https://orcid.org/0000-0002-9790-9581)
- Jingjing Xia (ORCID: https://orcid.org/0000-0002-2892-4032)
- Na He (ORCID: https://orcid.org/0000-0001-5560-5312)
- Hao Yin (ORCID: https://orcid.org/0000-0003-4921-9786)
- Yingying Ding (ORCID: https://orcid.org/0000-0001-6533-8035)
- Feng Cheng (ORCID: https://orcid.org/0000-0002-0148-7311)
- Xiaoxiao Chen (ORCID: https://orcid.org/0009-0006-8369-0570)
- Haijiang Lin
- Weiwei Shen (ORCID: https://orcid.org/0000-0002-6893-5158)
- Jiayu He (ORCID: https://orcid.org/0000-0002-3624-1178)
Institutions
- Fudan University (CN)
- Shanghai Public Health Clinical Center (CN)
- Ministry of Education (KR)
- Zhejiang Center for Disease Control and Prevention (CN)
- Yiwu Science and Technology Research Institute (CN)
Publication Details
- Journal
- The Journal of Clinical Endocrinology & Metabolism
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1210/clinem/dgaf331
- Citations
- 1
- Primary Topic
- HIV-related health complications and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.25
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China