Self-immolative PEGylated dendritic drug conjugates for cancer therapy with enhanced cellular uptake
A hypoxia-responsive nanomedicine NM-CB/Ce6 with prominent biocompatibility for co-delivering chlorambucil (CB) and chlorin e6 (Ce6) was prepared using a self-immolative PEGylated dendritic drug conjugate block-dendritic-polymer. Upon 650 nm near-infrared light (NIR) irradiation, the encapsulated Ce6 consumes oxygen to generate singlet oxygen (<sup>1</sup>O<sub>2</sub>) for photodynamic therapy (PDT). Under NIR-induced aggravated hypoxia, this nanomedicine can facilitate cellular internalization owing to hypoxia-responsive dePEGylation, and further disintegrate inside HepG2 cells to rapidly release activated CB for chemotherapy (CT).
Authors
- Shaomin Cheng (ORCID: https://orcid.org/0000-0003-4848-2187)
- Yue Ding (ORCID: https://orcid.org/0000-0002-8857-4855)
- Yixin Zhang (ORCID: https://orcid.org/0000-0002-6669-4995)
- Xinyi Zuo
- Zuo‐Li Xia
- Tian Yan-wen
Institutions
- Nantong University (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02776d
- Citations
- 2
- Primary Topic
- Dendrimers and Hyperbranched Polymers
- Type
- article
- Field-Weighted Citation Impact
- 1.21
Funders
- Natural Science Foundation of Jiangsu Province