<i>AKT1</i> Functional Polymorphism (rs2494750) Influences Clinical Outcomes in Patients With Advanced Lung Cancer Treated With EGFR Inhibitors
The <i>AKT1</i> rs2494750G>C polymorphism reduces promoter activity and gene expression of AKT1, potentially contributing to improved clinical outcomes in patients with advanced lung cancer treated with EGFR-TKIs.
Authors
- Shin Yup Lee (ORCID: https://orcid.org/0000-0002-2121-7335)
- Mi Jeong Hong (ORCID: https://orcid.org/0000-0002-9504-334X)
- Sun Ha Choi (ORCID: https://orcid.org/0000-0002-9665-7466)
- Won Kee Lee (ORCID: https://orcid.org/0000-0003-4217-5792)
- Seung Soo Yoo (ORCID: https://orcid.org/0000-0002-7309-9254)
- Jin Eun Choi (ORCID: https://orcid.org/0000-0001-7833-2257)
- Chang Ho Kim (ORCID: https://orcid.org/0000-0002-1550-5752)
- Jang Hyuck Lee (ORCID: https://orcid.org/0000-0001-5537-3013)
- Hyewon Seo (ORCID: https://orcid.org/0000-0003-0533-8863)
- Sook Kyung (ORCID: https://orcid.org/0000-0002-3829-3828)
- Hyo-Gyoung Kang (ORCID: https://orcid.org/0000-0003-0600-227X)
- Seung Ick (ORCID: https://orcid.org/0000-0002-7246-0909)
- Ji Eun Park (ORCID: https://orcid.org/0000-0002-4202-3126)
- Jaehee Lee (ORCID: https://orcid.org/0000-0001-8111-7320)
- Jae Yong Park (ORCID: https://orcid.org/0000-0001-7993-4495)
- Yong Hoon Lee (ORCID: https://orcid.org/0000-0001-5972-2866)
Institutions
- Kyungpook National University Hospital (KR)
- Kyungpook National University (KR)
Publication Details
- Journal
- Journal of Korean Medical Science
- Published
- 2025-01-01
- DOI
- https://doi.org/10.3346/jkms.2025.40.e184
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Kyungpook National University