The Role of cGAS STING Pathway in Neurodegen Erative Mechanisms and Progressive Diseases

cGAS-STING通路是胞质核酸识别免疫系统的重要组成部分，能够感知外来或自身错位DNA并激活免疫反应。研究表明，cGAS-STING通路是激活神经炎症的关键，在神经退行性疾病的发生发展中发挥了重要作用。深入了解cGAS-STING通路的作用机制有望为神经退行性疾病的诊断和治疗提供有效思路。基于此，本文对cGAS-STING通路在神经退行性疾病中的作用机制研究进展进行综述，旨在为神经退行性疾病的病理研究及治疗方案开发提供参考依据。cGAS-STING pathway is an important part of cytoplasmic nucleic acid recognition immune system, which can sense foreign or self-dislocated DNA and activate immune response. Studies have shown that cGAS-STING pathway is the key to activate neuroinflammation and plays an important role in the occurrence and development of neurodegenerative diseases. Understanding the mechanism of cGAS-STING pathway is expected to provide effective ideas for the diagnosis and treatment of neurodegenerative diseases. Based on this, this paper reviews the research progress on the mechanism of cGAS-STING pathway in neurodegenerative diseases, aiming at providing reference for pathological research and treatment development of neurodegenerative diseases.