Direct <i>N</i>-methyl C–H esterification of <i>O</i>-tosyl hydroxamates to enable facile synthesis of hemiaminal esters

Here we present a new method for synthesizing amide hemiaminal esters through the direct <i>N</i>-methyl C-H esterification of <i>O</i>-tosyl hydroxamates. This approach demonstrates good tolerance for a variety of functional groups and operates under mild, transition-metal-free conditions, thus providing an accessible and effective pathway to hemiaminal esters.

Authors

Jianjun Dai (ORCID: https://orcid.org/0000-0001-7918-0080)
Hua Xiao (ORCID: https://orcid.org/0000-0001-6100-0969)
Zhiwen Luo
Yan Pan (ORCID: https://orcid.org/0009-0003-3422-4635)
Heng Yang (ORCID: https://orcid.org/0000-0001-7431-932X)
Jicheng Wu (ORCID: https://orcid.org/0000-0002-6580-3416)
Fei Cao

Institutions

Hefei University of Technology (CN)

Publication Details

Journal: Chemical Communications
Published: 2025-01-01
DOI: https://doi.org/10.1039/d5cc02570b
Citations: 1
Primary Topic: Synthesis and Catalytic Reactions
Type: article
Field-Weighted Citation Impact: 0.94

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article

Direct N-methyl C–H esterification of O-tosyl hydroxamates to enable facile synthesis of hemiaminal esters

Jianjun Dai, Hua Xiao, Zhiwen Luo, Yan Pan et al.

Jan 1, 2025

1 citations

Chemical Communications

Synthesis and Catalytic Reactions

0.94

article

Direct N-methyl C–H esterification of O-tosyl hydroxamates to enable facile synthesis of hemiaminal esters

Jianjun Dai, Hua Xiao, Zhiwen Luo, Yan Pan, Heng Yang, Jicheng Wu, Fei Cao

January 1, 2025article en

1 citations

Abstract

Here we present a new method for synthesizing amide hemiaminal esters through the direct <i>N</i>-methyl C-H esterification of <i>O</i>-tosyl hydroxamates. This approach demonstrates good tolerance for a variety of functional groups and operates under mild, transition-metal-free conditions, thus providing an accessible and effective pathway to hemiaminal esters.

Chemical CommunicationsVol. 61(57)

Hefei University of Technology (CN)

Openalex Percentile: Top 25%

Synthesis and Catalytic Reactions

0.94

DOI Source OpenAlex

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