Regulatory TCRαβ+ Double Negative T Cells Suppress γδ T Cells and Alleviate Colitis
Among the diverse populations of DNT subsets, regulatory DNT cells are capable of accumulating in the inflamed colon, thereby preventing the progression of colitis through the suppression of CD103<sup>+</sup> γδ T-cell responses. The adoptive transfer of DNT cells could be a novel therapeutic strategy for inflammatory bowel disease.
Authors
- Shiyang Huang (ORCID: https://orcid.org/0000-0002-1273-4621)
- Dong Zhang (ORCID: https://orcid.org/0000-0002-3404-5173)
- Mingyang Li (ORCID: https://orcid.org/0000-0003-1766-7867)
- Lijun Pan (ORCID: https://orcid.org/0000-0002-0541-5323)
- Dan Tian (ORCID: https://orcid.org/0000-0002-6894-2673)
- Yuxi Zhang (ORCID: https://orcid.org/0000-0002-8335-1740)
- Yue Tian (ORCID: https://orcid.org/0000-0003-2522-7263)
Institutions
- Capital Medical University (CN)
- Beijing Chao-Yang Hospital, Capital Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101553
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Beijing Municipal Education Commission
- Natural Science Foundation of Beijing Municipality
- Beijing Municipal Science and Technology Commission
- Beijing Municipal Administration of Hospitals