LINC02888 promotes HGSOC progression and immune evasion via PPIB-mediated stabilization of LAPTM5 mRNA and inhibition of RIG-I-like receptor signaling
Our findings reveal that LINC02888 drives HGSOC progression through a mechanism involving PPIB-mediated stabilization of LAPTM5 mRNA, which suppresses RIG-I-like receptor signaling. It also appropriately suggests that inhibiting this innate immune pathway may contribute to an immunosuppressive tumor microenvironment, making the LINC02888-PPIB-LAPTM5 axis a promising therapeutic target for this aggressive malignancy.
Authors
- Reuben He (ORCID: https://orcid.org/0000-0001-8541-5464)
- Zheng Kuang (ORCID: https://orcid.org/0000-0002-8281-677X)
- Yanfeng Yang
- Bo Ren (ORCID: https://orcid.org/0000-0001-8332-3611)
- Bei-bei Rui
- Tianhao Mu (ORCID: https://orcid.org/0000-0003-0177-7121)
- Xiaowei Zhang (ORCID: https://orcid.org/0000-0002-2016-4032)
- Yunlong Zhang (ORCID: https://orcid.org/0000-0003-4239-1786)
- Yu-xi Liu (ORCID: https://orcid.org/0000-0002-3961-2691)
- Min Wang (ORCID: https://orcid.org/0009-0003-1566-9516)
- Danbo Geng
Institutions
- University of British Columbia (CA)
- China Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s12967-025-06650-9
- Citations
- 1
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Key Technologies Research and Development Program
- Shengjing Hospital