Cellular imbalance in proximal and distal lung of CFTR−/− sheep in utero and at birth
The differences in epithelial cell abundance observed in the CFTR<sup>-/-</sup> lambs at term may reflect sequelae from the loss of CFTR on lung development and differentiation in utero. These findings provide novel insights into the cellular mechanisms of pathology and may be relevant to the design of new therapeutic approaches for CF lung disease.
Authors
- Svyatoslav Tkachenko (ORCID: https://orcid.org/0000-0001-8687-1576)
- Iuri Viótti Périssé (ORCID: https://orcid.org/0009-0002-7934-836X)
- Kenneth L. White (ORCID: https://orcid.org/0000-0003-0368-886X)
- Jenny L. Kerschner (ORCID: https://orcid.org/0000-0002-1980-2543)
- Irina A. Polejaeva (ORCID: https://orcid.org/0000-0002-0858-5889)
- Arnaud J. Van Wettere (ORCID: https://orcid.org/0000-0002-9611-1316)
- Tayler Patrick (ORCID: https://orcid.org/0000-0001-7989-9634)
- Shih‐Hsing Leir (ORCID: https://orcid.org/0000-0001-9524-3379)
- Alekh Paranjapye (ORCID: https://orcid.org/0000-0002-4069-1761)
- Ann Harris (ORCID: https://orcid.org/0000-0002-6541-2546)
- Ying Liu (ORCID: https://orcid.org/0000-0002-6540-0473)
- Cheyenne M. Marriott
Institutions
- Utah State University (US)
- University School (US)
- Case Western Reserve University (US)
- University of Pennsylvania (US)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-06-11
- DOI
- https://doi.org/10.1186/s10020-025-01266-7
- Citations
- 1
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- U.S. Department of Agriculture
- Cystic Fibrosis Foundation
- Utah Agricultural Experiment Station
- Case Western Reserve University